I. Ullah

COMPARATIVE EFFECTS OF ONDANSETRON AND METOCLOPRAMIDE WITH POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS UNDERGOING BARIATRIC SLEEVE GASTRECTOMY

Background: Postoperative nausea and vomiting (PONV) are among the most common complications following bariatric sleeve gastrectomy. PONV can delay recovery, increase patient discomfort, prolong hospital stay, and negatively affect overall surgical outcomes. Ondansetron and metoclopramide are commonly used antiemetic a...

Pdx–MgO1−x/rGO enzyme-mimetic nanozymes for photocatalytic hydrogen evolution and dye degradation

The development of efficient, sustainable nanozymes that act as photocatalysts for solar hydrogen (H2) evolution remains a critical research priority in clean energy technologies. In this work, multifunctional Pdx–MgO1−x/rGO (x = 0, 0.3, 0.5, 0.7; where x represents the weight fraction of Pd within a total metal loadin...

Monitoring Urban Sprawl Dynamics Through Spatiotemporal Analysis Using Normalized Difference Built-up Index in Mardan City, Pakistan

The assessment of  spatial distrubution and expansion-driven urban sprawl is cruical for effective urban planning and ensuring sustainable resource management. This study presents a spatiotemporal assessemnt of urban expansion dynamics in Mardan City, Pakistan, by employing the Normalized Difference Built-up Index in t...

Techniques for Accelerating the Understanding of PROTAC-Based Ternary Complex.

Mechanism of Qilu Buxue granules in alleviating chemotherapy-induced leukopenia: Insights from network pharmacology, integrated omics, and experimental validation.

ETHNOPHARMACOLOGICAL RELEVANCE Leukopenia is a prevalent side effect of cancer chemotherapy, characterized by fever, fatigue, weakness and a significantly elevated risk of life-threatening infection. Qilu buxue granules (QBG) are clinically utilized to mitigate cyclophosphamide-induced leukopenia (CTX-IL), but the prec...

In-silico Identification of Cyclic Peptide Inhibitors for A42r Profilin-like Protein from Monkeypox Virus.

The objective of the present study was to identify cyclic peptides CycPept_3468 and CycPept_4348, which showed excellent inhibitory activity against the MPXV A42R profilin-like protein, indicating their potential efficacy as antiviral drugs.

Drug-likeness defects drive carrier-free cyanine-PROTAC self-assembly for tumor-specific protein degradation.

A versatile supramolecular strategy that directly addresses the long-standing delivery challenges of PROTACs and advances precise, controllable oncological therapy is established.

Exploring the role of nature-based solutions for climate adaptation in the agriculture sector

Climate change impacts are more severe and frequent in countries vulnerable to climate. Evidence indicates that Nature-based solutions (NbS) are widely used as cost-effective and sustainable adaptation strategies; however, their effectiveness varies across ecological, institutional, and socio-economic contexts. Our und...

A Tissue-Homologous Keratin-PBA Hydrogel Integrating Rationally Designed Nanomicelles Enables Microenvironment-Adaptive Repair of Chronic Diabetic Wounds.

A tissue-homologous, intelligently adaptive platform integrating intrinsic regenerative bioactivity with glucose-responsive therapeutic adaptability is presented, as evidenced by rapid wound closure, enhanced M2 macrophage polarization, robust neovascularization, improved collagen remodeling, and increased granulation...