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I. Vascotto

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Review Open access Nov 2026

Trastuzumab deruxtecan in HER2-expressing urothelial carcinoma: current evidence, biomarker challenges, and future therapeutic strategies.

INTRODUCTION Urothelial carcinoma (UC) has become a prototype for antibody-drug conjugate (ADC)-based therapy, but relapse after first-line enfortumab vedotin plus pembrolizumab remains common. HER2 protein expression, ERBB2 amplification and activating mutations identify overlapping but distinct populations; this revi...

G. Roviello, K. Shtembari, I. Vascotto et al. · 0 citations

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