Senescence Markers and Associated Transcriptomic Changes Are Expressed at Early Stages of Alzheimer’s Neuropathology but Are Not Independently Related to Dementia
Cellular senescence may affect the post-mitotic cells of the brain. We examined the expression of senescence markers, including p16, p21, γH2Ax and H3K9me3, in the frontal cortex of brain donations from the Cognitive Function and Ageing Study to assess their relationship to Alzheimer’s disease neuropathological change...