Author

Iain D. C. Fraser

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Open access Aug 2026

Novel gain-of-function mutation in dysferlin causes vesicle trafficking defect and IL-1 mediated autoinflammation

Dysferlin is identified as a regulator of membrane homeostasis in myeloid cells, defective membrane-stress adaptation as trigger of NLRP3 inflammasome activation is established, and a novel IL-1 mediated autoinflammatory disease caused by gain-of-function DYSF mutations is defined.

Farzana Bhuyan, Clinton J. Bradfield, Amitava Roy et al. · medRxiv · 0 citations

Open access Jul 2026

Investigating Inflammasome Responses to Pathogenic Fungi 2331094

This work aims to understand the molecular mechanisms governing fungal intracellular sensing and inflammasome activation, to provide critical insights into host—fungi interactions and inform the development of therapies for the increasing emergence of invasive and inflammatory fungal diseases.

Ronit Schwartz Wertman, Clinton Bradfield, Eric Van Dang et al. · Journal of Immunology · 0 citations