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Ian McBain

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Jul 2026

Decoding the role of CD4 T cells in driving autoimmune type 1 diabetes 2333351

Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease where CD8 T cells eliminate insulin-producing β cells in the pancreatic islets. Yet, MHC class II haplotypes confer the greatest genetic risk for the development of T1D, suggesting a critical role for CD4 T cells. Employing the non-obese diabetic (NOD)...

Ian McBain, P. Zumbo, S. Miakicheva et al. · 0 citations

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