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Ignacio Gallardo

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Open access Aug 2026

α-Synuclein aggregates in corticostriatal terminals impair glutamatergic transmission in the absence of neurodegeneration

Formation of presynaptic α-synuclein aggregates impairs corticostriatal function without degeneration of cortical neurons or striatal dopamine terminals, suggesting pathologic α-synuclein is sufficient for synaptic loss.

Charlotte F. Brzozowski, Zoe Fokakis, Marissa A. Menard et al. · 0 citations

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