Review
Open access
Sep 2026
The NLRP3 inflammasome in physiological and dysfunctional host response in human sepsis and critical illness: a narrative review
The NLRP3 inflammasome is a cytosolic multiprotein complex that serves as a key regulator of innate immunity by reacting to pathogen- and damage-associated signals and orchestrating downstream inflammatory responses. Inflammasome activation induces caspase-1-dependent maturation of interleukin (IL)-1β, IL-18 and gasder...
Caroline Neumann, Florian Hickl, Julia Kemnitzer et al.
· Critical Care · 0 citations