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Author

Igor B. Zhulin

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Open access Aug 2026

Evolution of monomodular all-helical receptor ligand-binding domains from bimodular ancestors.

Bacterial chemotaxis is essential for environmental adaptation and host interaction. To this end, bacteria have evolved exceptionally broad chemosensory capacities, with few apparent constraints on ligand structure or size. These capacities are determined by the extraordinary diversity of chemoreceptor ligand-binding d...

J. Gavira, Miriam Rico-Jiménez, Á. Ortega et al. · 0 citations
Open access Jul 2026

Decoding functional specialization in G protein‐coupled receptors (GPCRs) through evolution‐guided residue profiling

G protein‐coupled receptors are integral membrane proteins that mediate physiological processes by enabling cells to detect and respond to diverse stimuli by enabling cells to detect and respond to diverse stimuli.

Berkay Selçuk, Gunnar Schulte, Igor B. Zhulin et al. · 0 citations

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