Author

Igor Chernukhin

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Sep 2026

Abstract A094: Mapping early Pancreatic Cancer evolution through enhancer reprogramming and transcription factor interactomes

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with poor survival largely driven by late-stage diagnosis. Approximately 85% of patients present with advanced disease, limiting curative treatment options. A major challenge in PDAC is the absence of biomarkers capable of identify...

Paula D. Santos, Lisa Young, Sarah Baloul et al. · Cancer Research · 0 citations

Open access Aug 2026

GATA3-extension mutants rewire lineage identity in luminal breast cancer

It is shown that eGATA3 is associated with poor clinical outcome and remodels the luminal transcriptional program, leading to attenuation of estrogen-responsive transcription and progressive loss of luminal differentiation.

Nivedhya Venas, Mrunal Ratnaparkhi, Kartik Majila et al. · bioRxiv · 0 citations