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Ikuko Omori

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Open access Sep 2026

The CD112-TIGIT/PVRIG Axis Mediates NK Cell Evasion in Decitabine-Treated Acute Myeloid Leukemia Cells

Findings identify CD112 upregulation, which is associated with enhancer demethylation, as a mechanism of drug-induced immune evasion in AML and provide a rationale for combining hypomethylating agents with blockade of the CD112-TIGIT/PVRIG axis to enhance NK cell-mediated antileukemic activity.

Keisuke Nakamura, Ikuko Omori, Naru Sato et al. · 0 citations

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