Open access
Aug 2026
Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis.
Amyloid fibrils, crystal-like aggregates of denatured proteins, form upon breakdown of supersaturation and underlie amyloidosis in diseases, such as Alzheimer's, Parkinson's, and amyloidogenic light chain (AL) disease. In AL amyloidosis, fibrils accumulate in the heart, where they are exposed to shear stress. To mimic...
Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima et al.
· The FEBS Journal · 0 citations