Ilja C. W. Arts

Network-based stratification of allele-specific expression reveals patient subgroups in Huntington’s disease

By propagating gene-level ASE imbalance profiles through a protein-protein interaction network, 20 HD patients are stratified into three distinct biological patient subgroups, highlighting neuroinflammatory pathways as key sources of inter-patient heterogeneity and transcriptional regulatory variation as a potential co...