Bioengineered Amphiphilic Chitosan Nanocarriers for Improved Oral Absorption of Poorly Soluble Antihypertensive Agents.
The clinical efficacy of many antihypertensive medications is constrained by their poor water solubility, low membrane permeability, significant first-pass metabolism, and uncertain oral bioavailability, even though hypertension is still a major worldwide health concern. For BCS Class II and IV medications like telmisa...