MCC950-Derived NLRP3 Inflammasome Inhibitor Modulates Glial Inflammatory Signatures and Neuroinflammation after Traumatic Brain Injury
The NLRP3 inflammasome is a central mediator of sterile inflammation and a key therapeutic target to modulate secondary neuroinflammation following traumatic brain injury (TBI). Although the widely used NLRP3 inhibitor MCC950 effectively suppresses inflammasome activation in preclinical models, its clinical developme...