Structural complexity in biological matter arises from molecular information that encodes supramolecular assembly across length scales1, 2–3. Here we show that minimal nine-residue peptides can encode discrete lateral interaction motifs that direct supramolecular organization. These motifs generate hexagonal pores and...
Jasmina Gačanin, Francesca Mazzotta, Luis A. Baptista et al.· Nature· 0 citations
Almost all membrane proteins are inserted or translocated across membranes by the universally conserved Sec translocon. Despite its central role, experimental access to Sec function has remained limited. Here, we present ProSecCO (Protein Secretion in Cell-free via synthetic Operons), which is a cell-free protein synth...
M. Meier, Scott A. Scholz, Leo von Bank et al.· Science Advances· 2 citations
Cholesterol is a key determinant of membrane stability and fluidity in both natural and synthetic lipid systems. Although widely used, its content varies greatly among commercial liposomes, and its regulatory effects on biological interactions remain insufficiently understood. Here, we reveal that cholesterol content...
Fangqin Fu, Yuting Ge, Xuemei Hu et al.· ACS Nano· 0 citations
Amyloid polymorphism is important in neurodegenerative and metabolic disease. Understanding fibril molecular polymorphism is critical to understanding why certain protein aggregates made from the same protein are pathogenic while others are benign. Here, we generate two polymorphs of human insulin, as a model system,...
Elnaz Hosseini, Saeid Hadi Alijanvand, Y. Kan et al.· Communications Chemistry· 0 citations
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