Author

Innesa Leonovich

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Open access Sep 2026

Intrinsically disordered regions navigate DNA replication licensing factors to specific genomic loci

Sites of DNA replication initiation are determined by binding of the Origin Recognition Complex (ORC, composed of Orc1-6) to specific genomic loci. Here, we determine the mechanism underlying site-specific binding of human Orc1. We find that Orc1’s Bromo-Adjacent Homology (BAH) domain functions as an avidity element, w...

Innesa Leonovich, M. Parker · bioRxiv · 0 citations

Open access Aug 2026

Phosphorylation alters the bulk chemical properties of Orc1 to tune DNA binding, phase separation, and heterochromatin partitioning

It is demonstrated that phosphorylation tunes the biochemical properties of the Orc1 IDR to control DNA binding, phase separation, and, consequentially, heterochromatin recruitment and suggests that localized dephosphorylation of the DNA binding Orc1 IDR may underlie recruitment of ORC to specific genomic loci.

Olubu A. Adiji, Innesa Leonovich, M. Parker · bioRxiv · 1 citation