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Author

Ioannis Sarropoulos

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Open access Oct 2026

Reconstructing human gene regulatory evolution using deep learning

Understanding the genetic changes that drove the evolution of human-specific traits is a central goal in biology. Changes in gene expression are thought to be a major source of phenotypic innovations1,2, but identifying the underlying changes in cis-regulatory elements (CREs) along the human lineage has been difficult:...

Tetsuya Yamada, Xue-Fei Yuan, Hugo Zeberg et al. · 0 citations
Open access Jul 2026

Unravelling gene regulatory networks and driver TFs in CD4+ regulatory T cell development in the human thymus 2308489

This framework provides an important mapping of GRNs involved in thymic T cell differentiation, particularly focusing on Tregs and will serve as an important basis for understanding Treg biology and improving Treg-based therapies.

B. Lee, Ioannis Sarropoulos, Yoonseo Park et al. · 0 citations

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