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Author

Ipek Ilgin Gönenç

2 papers indexed here

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Open access Aug 2026

DDIAS shields single-stranded DNA in mitosis and promotes vertebrate brain development.

DNA double-strand breaks and unresolved DNA replication intermediates are particularly dangerous during mitosis. Paradoxically, cells inactivate canonical DNA repair mechanisms during chromosome segregation in favor of alternative pathways that depend on TOPBP1 and CIP2A, but how these pathways function is still poorly...

Kaima Tsukada, L. Lototska, A. Tsukada et al. · 2 citations
Open access Aug 2026

Distinct mitochondrial DNA single-nucleotide variant signatures in TOP3A-deficient cardiomyocytes

The human heart has a continuous and exceptionally high demand for energy, which is met primarily through mitochondrial oxidative phosphorylation. This dependence places the maintenance and integrity of mitochondrial DNA (mtDNA) for proper mitochondrial function at the center of cardiac health, as mtDNA instability has...

Marianne Gaubert, Halima Alachram, Ipek Ilgin Gönenç et al. · 0 citations

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