Irina V. Balyasnikova

Improving T-cell engager efficacy in glioblastoma with multi-antigen targeting and novel delivery approaches

Glioblastoma remains a challenging disease to approach with immunotherapy due to pronounced antigen heterogeneity, immunosuppressive tumor microenvironment, and barriers to effective molecule delivery within the central nervous system. T-cell engagers provide an off-the-shelf approach to redirect endogenous T cells tow...