Virion-wide interactome mapping of HSV-1 reveals maturation-dependent remodeling and convergent organization of herpesvirus tegument networks
A virion-wide spatial and quantitative protein proximity map of herpes simplex virus 1 (HSV-1) is defined by combining cross-linking mass spectrometry with quantitative proteomics, showing how conserved organizational principles shape virus-specific virion interaction networks during herpesvirus maturation.