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Isa Madrigal Harrison

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Open access Aug 2026

Combining Machine Learning and Directed Evolution for Optimization of a Monooxygenase

A systematic comparison of zero-shot ML models is provided and an iterative framework for integrating machine learning with directed evolution to accelerate enzyme engineering is established to accelerate enzyme engineering.

Daniel Gutierrez, Isa Madrigal Harrison, Aaron L. Feller et al. · 0 citations