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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Isabelle Coste

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2 papers indexed here

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Open access Sep 2026

A sensitive Interactome-based approach to characterize drug activity in living human cells.

Abnormal protein-protein interactions (PPIs) involving signaling proteins contribute to numerous human diseases. Targeting such aberrant PPIs with selective inhibitory molecules is a promising therapeutic strategy, yet assessing how many PPIs are affected by a candidate drug, and whether inhibition occurs before or aft...

Cindy Kundlacz, C. Forcet, Nawal Hajj Sleiman et al. · 0 citations
Open access Jul 2026

Non-canonical signaling hubs upon inhibition of MyD88-ERK interaction in cancer

It is demonstrated that perturbation of the ERK-MyD88 complex rewires cellular signaling into cell-autonomous hubs that coordinate caspase activation with chemokine secretion, thereby driving a program of immunogenic cancer cell death.

Nader Hussein, Najwa Skafi, Thuy Ha Pham et al. · 0 citations

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