Uncovering the signaling networks of disseminated glioblastoma cells in vivo with INSIGHT
INvestigating SIGnaling network of specific cell subpopulation in Heterogeneous Tissue, a new platform technology combining fluorescence-activated cell sorting with ultra-sensitive mass spectrometry to enable phosphoproteomic characterization of rare and discrete cell subpopulations from fixed tissues, uncovered a global rewiring of signaling networks with tumor cell dissemination.