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Ivaila Kuleva

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Review Open access Oct 2026

Complement in HER2-Positive Breast Cancer: A Conditionally Protective Mechanism Under Attack

The therapeutic efficacy of anti-HER2 monoclonal antibodies in breast cancer has traditionally been attributed to direct inhibition of signaling and antibody-dependent cellular cytotoxicity (ADCC). Recent evidence, however, has established complement activation through the classical pathway as a possible adjunct mechan...

D. Petkova, Ivaila Kuleva, Zhasmina Stoyanova et al. · 0 citations

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