Author

Ivan Dubois

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Open access Oct 2026

Population diversity and accelerated mutation drive anaerobic bacterial adaptation during long-term solvent stress

Investigating evolutionary trajectories of the anaerobic, lignocellulose-fermenting bacterium Lachnoclostridium phytofermentans ISDg during >2,000 generations of automated, log-phase selection at progressively increasing butanol concentrations provides insights into the mechanisms by which anaerobes acquire tolerance t...

Tom Zaplana, Magali Boutard, Ivan Dubois et al. · mSystems · 0 citations

Jul 2026

Metabolic adaptation enabling D-xylose assimilation via the Entner-Doudoroff pathway in glycolysis-impaired Escherichia coli strains.

This study revealed that mutations in key enzymes and transcriptional regulators at various metabolic branching points were essential for effective growth on D-xylose, enabling optimized partitioning of carbon through central metabolism despite the loss of the canonical EMP glycolytic route.

C. Iacometti, Valérie A. Delmas, Mélodie Cadillon et al. · Metabolic Engineering · 0 citations