Review
Open access
Sep 2026
Machine learning and computational approaches to model therapeutic response and resistance in diffuse midline glioma
Diffuse midline glioma (DMG) remains one of the most lethal cancers affecting children, adolescents and young adults and is near-universally resistant to treatment. Histone H3-alterations establish a profoundly dysregulated epigenetic landscape that promotes extensive intratumoral heterogeneity and cellular plasticity,...
O. Dubois, Olive E. L. Loughnan, Yuan-Hao Jiang et al.
· Journal of Neuro-Oncology · 0 citations