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Author

J. A. Carvalho

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Open access Oct 2026

Nanostructured Hybrid Matrix Device: An Engineered Approach for Localized Photodynamic Therapy in 9L/lacZ Cell Models

Gliosarcoma treatment remains a challenge due to its aggressiveness and high recurrence rates. This study describes the development and characterization of a novel hybrid drug delivery system (DDS) for localized photodynamic therapy (PDT). The system consists of a PVA/gelatin hydrogel encapsulated with hydroxyapatite m...

J. A. R. Ambrósio, J. A. Carvalho, Letícia G. M. Pinto et al. · 0 citations
Open access Oct 2026

Highly Stable PLA/Gelatin Bionanocomposites for Enhanced Delivery of Chloroaluminum Phthalocyanine for Photodynamic Therapy against SK-MEL-28 Cells

This study reports the development of a biodegradable poly(lactic acid) and gelatin (nPLA-G) bionanocomposite as a drug delivery system for chloroaluminum phthalocyanine (ClAlPc) in photodynamic therapy (PDT). Using a hybrid desolvation/emulsification technique, we engineered spherical nanoparticles with an average d...

J. A. Carvalho, J. A. R. Ambrósio, M. Beltrame et al. · 0 citations

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