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Author

J. Abraham

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Open access Aug 2026

Orthoflaviviruses use diverse binding modes to engage LDLR family receptors

Cryo-electron microscopy structures of yellow fever virus (YFV) E bound to low-density lipoprotein receptor-related protein 4 (LRP4) and LRP8, and of tick-borne encephalitis virus (TBEV) E bound to LRP8 are determined, identifying key determinants of receptor specificity for these two orthoflaviviruses.

Chenggong Ji, Laurentia V. Tjang, Biswajit Das et al. · 0 citations
Open access Jul 2026

Molecular basis for chikungunya virus recognition of a mosquito-specific receptor

High-resolution cryo-electron microscopy structures of alphaviruses bound to Aedes albopictus Lachesin define distinct determinants of receptor binding in mosquitoes and humans for arthritogenic alphaviruses, with implications for countermeasure development and outbreak preparedness.

Xiao-Yi Fan, Wan-Yu Li, Jesse S. Plung et al. · 0 citations
Open access Sep 2026

Structure and operating principles of a monkeypox virus replisome

Poxviruses are double-stranded DNA viruses with large genomes. Among them, monkeypox virus (MPXV) has been responsible for two recent public health emergencies as declared by the World Health Organization1. The MPXV polymerase comprises three subunits—a catalytic subunit (F8) and a heterodimeric processivity factor (A2...

Zi-Shuo Yu, Pradeep Sathyanarayana, Joel M. J. Tan et al. · 0 citations

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