Sep 2026
Phosphodiesterase 4 Inhibition Attenuates Diet-Induced Obesity and Activates BAT Thermogenic Pathways Through Central Mechanisms.
ARTICLE HIGHLIGHTS Metabolic alterations in obesity encompass impaired thermogenesis and sympathetic activity, underscoring the need for new metabolic targets to treat this disease. This study tested whether inhibition of PDE4 by rolipram enhances energy expenditure and brown adipose tissue activity. Rolipram reduced b...
Hellen Veida-Raposo, M. A. C. de Andrade, P. Zarpellon et al.
· Diabetes · 0 citations