Lipotoxicity Amplifies IL-6 Trans-Signaling in Sinusoidal Endothelial Cells to Promote Endotheliopathy and Liver Injury.
BACKGROUND AND AIMS Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 25% of the global population and is a major health concern. Liver sinusoidal endothelial cells (LSECs) undergo morphological and functional alterations during MASLD progression, resulting in endotheliopathy charac...