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Review Open access Aug 2026

A proposal of good manufacturing practices (GMP) laboratory for CAR T-cell therapy in Latin America and the Caribbean: challenges and opportunities

This model advocates for decentralized, modular cleanroom facilities that integrate fully closed automated manufacturing platforms with risk-based quality management systems and emphasizes the strategic implementation of artificial intelligence (AI) and digital health tools—such as electronic batch records and predicti...

S. Cabrera-Salcedo, L. Parra-Lara, Mónica Fernandes-Pineda et al. · 0 citations
Review Open access Aug 2026

Clinical evidence on non-viral CAR-T cell therapies for solid tumors: a scoping review

Background Chimeric antigen receptor (CAR) T-cell therapy in solid tumors is hindered by the immunosuppressive tumor microenvironment and by toxicities associated with viral-vector manufacturing. Non-viral gene delivery platforms have emerged as a potential alternative, though clinical evidence remains fragmented. Meth...

Favio Varón Suárez, J. Moreno, Oriana Arias-Valderrama et al. · 0 citations

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