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Review Open access Aug 2026

Worldwide Innovative Network Consortium: Building a Common Global Cancer Database

This review shares the ongoing work of the global Worldwide Innovative Network (WIN) Consortium for Precision Medicine to synthesize emerging cancer treatment data and to define the requirements for a common global cancer database that can truly support precision oncology. We performed a narrative review of emerging ca...

Farhood Farahnak, W. El-Deiry, Yves A. Lussier et al. · 0 citations
Open access Jul 2026

PD-L1 and PD-L2 regulate in cell-autonomous and N-glycosylation-dependent manners the pro-tumorigenic characteristics and functions of human cancer-associated fibroblasts.

BACKGROUND Tumor progression is regulated by cancer-associated fibroblasts (CAFs), pro-inflammatory cytokines (e.g., TNFα, IL-1β, IFNγ) and acquired immunity (such as inhibitory immune checkpoints: PD-L1, PD-L2). Here, we determined the interactions between these elements by analyzing the impact of pro-inflammatory cyt...

Alaa Abu Raiya, Tsipi Meshel, I. Kamer et al. · 0 citations

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