Somatic likelihood tiering: an interpretable post-calling triage protocol for tumor-only whole-exome variant review
Abstract Tumor-only whole-exome sequencing (WES) is used when matched normal tissue is unavailable, but one sample can produce thousands of variants. Somatic likelihood tiering (SLT) is an interpretable post-calling protocol that ranks Mutect2 calls into four review-priority tiers using population-frequency, germline-q...