J. Belyaeva

Reconstructing hidden GPCR conformations and ligand binding modes through integrative DEER modeling.

Binding of biased ligands to a G protein-coupled receptor (GPCR) stabilizes specific receptor conformations, leading to distinct physiological responses. Recently, intra-transducer bias has emerged as an additional mechanism that fine-tunes receptor function by stabilizing specific architectures of the receptor-transdu...