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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

J. Berger

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Open access Sep 2026

Variant-specific nucleocapsid mutations shape host innate immune trajectories during SARS- CoV-2 infection

It is found that the mutations induce distinct transcriptional and translational alterations: rN-Alpha drives a stealth-like infection characterized by sustained translation efficiency and specific evasion of the 2’-5’-oligoadenylate synthetase (OAS) innate immune sensor, whereas rN-Delta and rN-BA trigger a highly ele...

J. Berger, Jonas Schröder, Timothy K. Soh et al. · 0 citations
Open access Jul 2026

Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2

A complete structure-activity relationship of Mac1 of SARS-CoV-2, that was used to design potent nucleotide inhibitors, were reported, which were developed into membrane-permeable, non-toxic prodrugs, which strongly suppress viral replication.

Maximilian Sandmann, Sahra Tajdar, Simon Sander et al. · 0 citations

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