Author

J. Bernett

2 papers indexed here

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Open access Sep 2026

Towards reconstruction of the human interactome from positive and negative experimental evidence

Protein-protein interactions (PPIs) have been detected and reported in the millions, but while they are used in many different contexts for better understanding cellular processes in health and disease, the knowledge of the human PPI network is far from complete, containing many false positive measurements and being hi...

Joel Ås, K. Pelz, J. Bernett et al. · bioRxiv · 1 citation

#machine learning Preprint Sep 2026

Are You Learning Biological Signal or Shortcuts? Auditing and Mitigating Bias in Protein-Protein Interaction Datasets

Protein-protein interaction (PPI) databases do not faithfully reflect biological realities. Instead, they are influenced by study and technical biases that distort certain protein and interaction attributes. Machine learning models can exploit these as learning shortcuts if the negative dataset is not constructed with...

J. Bernett, A. Spannagl, Joel Ås et al. · 1 citation