Graph-based analysis of volumetric image data reveals predominant layer Va-to-II/III feedback in mouse motor cortex.
A graph-framework is developed to infer functional connectivity from fast volumetric two-photon Ca2+ imaging of spontaneous activity in the awake mouse primary motor cortex, revealing diverse column-like microcircuits in M1 with a net ascending flow, suggesting that such sub-networks form elemental processing modules f...