Open access
Nov 2026
Fungal suppression by bacterial metabolite-activated human intestinal γδT-cells is disrupted in Crohn's disease.
Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacterial metabolite HMB-PP is sensed by a specialized population of Vγ9Vδ2+T-cells, which we now report can potently suppress...
L. Mathew, S. Carlson, M. Savage et al.
· PLoS Biology · 0 citations