Aug 2026
MYC-MIZ1 Complexes at Enhancers Tune Neuroendocrine Identity of Small Cell Lung Cancer
L. Fröhlich, H. Tumbrink, Bikash Adhikari et al.
· bioRxiv · 0 citations
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Open access
Aug 2026
A targetable dependency on nonsense-mediated decay for cellular homeostasis and immune control in small cell lung cancer
This work identified that NMD inhibition boosted neoantigen expression and presentation by tumor cells and increased T cell recognition, thus enhancing overall tumor immunogenicity and further improving immunotherapy efficacy in vivo, uncovering a novel TMB-dependent tractable vulnerability for this devastating disease...
Lucia A. Torres-Fernández, V. Boehm, Joel Kaufmann et al.
· Molecular Cancer · 0 citations