Author

J. Bruand

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Open access Oct 2026

LRP2: A proteogenomics pipeline for long-read informed protein isoform analysis and discovery.

SUMMARY Most human genes produce multiple RNA isoforms, yet it remains unclear which isoforms are translated into stable, functional proteins. Long-read RNA sequencing resolves full-length transcript structures and, when paired with mass spectrometry, can provide empirical evidence of isoform translation. Despite this...

Megan D. Schertzer, Julia T. Lewandowski, Emily F. Watts et al. · Bioinformatics · 0 citations

Open access Sep 2026

Isocall enables scalable transcript identification from long-read RNA-sequencing data

Isocall, a scalable and deterministic computational method for jointly calling transcripts from multiple PacBio long-read RNA sequencing samples, converts aligned full-length non-concatemer reads into compact per-sample transcript profiles, merges these profiles across samples, and jointly identifies known and novel tr...

E. Dolzhenko, Megan D. Schertzer, Ryan Gossart et al. · bioRxiv · 1 citation