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Author

J. Buchner

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2 papers indexed here

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Open access Sep 2026

Antifungal metallacarboranes modulate Hsp90 activity

ABSTRACT Aims Despite growing interest in metallacarborane biological activity, the molecular targets underlying their antifungal activity remain unknown. This study aimed to identify protein targets of antifungal metallacarborane derivatives in Candida albicans and to characterize their interaction with the molecular...

K. Kubiński, Paweł Czubak, Aleksandra Martyna et al. · 0 citations
Open access Aug 2026

Constrictions and shear stress are key determinants of amyloidogenic light chain (AL) amyloidosis.

Amyloid fibrils, crystal-like aggregates of denatured proteins, form upon breakdown of supersaturation and underlie amyloidosis in diseases, such as Alzheimer's, Parkinson's, and amyloidogenic light chain (AL) disease. In AL amyloidosis, fibrils accumulate in the heart, where they are exposed to shear stress. To mimic...

Yuji Goto, Keiichi Yamaguchi, Kichitaro Nakajima et al. · 0 citations

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