J. Carlson

Meta-analysis of over 8,000 individuals from Hawai‘i and Samoa for genetic associations to cardiometabolic phenotypes

Although genome-wide association studies (GWAS) now routinely reveal genetic associations and biological insights in millions of individuals, underrepresentation of global populations, such as those from Polynesia, continue to persist. These exclusions, often driven by logistical challenges and lack of data, prevent sy...

CREBRF rs373863828 minimally regulates gene expression in subcutaneous adipose tissue of Samoan adults

Variant Harmonization Critically Determines Polygenic Score Transferability for Lipid Traits in Samoan Populations.

Dyslipidemia is a significant risk factor for cardiovascular disease (CVD), the leading cause of death in Samoa. Polygenic scores (PGS) for lipid traits offer promise for improved CVD risk prediction; however, their performance in Pacific Islander populations - comprising only 0.002% of GWAS participants as of 2024 - r...