CDH1 germline carriers and diffuse gastric Cancer: Are we ready for personalized surveillance and prevention?
Hereditary diffuse gastric cancer (HDGC) caused by germline pathogenic or likely pathogenic variants in CDH1 remains a difficult hereditary cancer syndrome to manage. Prophylactic total gastrectomy has long been considered the most definitive preventive strategy, but recent penetrance estimates, expert endoscopic surve...