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J. Chill

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Open access Aug 2026

Cdk1 and PP2A constitute a molecular switch controlling orderly degradation of atypical E2Fs.

A critical role for Cdk1-PP2A signaling is highlighted in controlling the orderly degradation of APC/C substrates, ensuring precisely timed assembly of the transcriptional infrastructure that coordinates cell cycle commitment and progression.

Sapir Nachum-Raines, Noy Gamliel, Danit Wasserman et al. · 0 citations
Open access Aug 2026

Regulation and dysregulation at a critical hematopoietic junction: The human WASP-WIP complex.

A structural viewpoint of WASP/WIP biology creates a much-needed molecular context for understanding hematopoietic cytoskeletal regulation in homeostasis and in WAS/XLT and is expected to be invaluable in the search for new therapeutic approaches to these rare diseases.

Inna Sasson, Saja Baluom, Adi Halle-Bikovski et al. · 0 citations
Aug 2026

Integrating Parallel-Bias Metadynamics-Metainference and Relaxation Dispersion NMR to Resolve Hidden Conformational States Driving Toxin-Channel Recognition.

Conformational dynamics in toxin inhibitors are an important contributor to ion channel affinity, yet toxin multidimensional energy landscapes remain largely unexplored. In the current work, we combine parallel-bias metadynamics-metainference (PBMetaD) simulations with relaxation dispersion NMR to define, at atomistic...

Chen Timsit Shmueli, Miriam Gulman, D. T. Major et al. · 0 citations

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