Breast cancer protective genetic variant common in women of Indigenous American genetic ancestry is a cis-eQTL for RMND1, ARMT1, and CCDC170 in HER2-enriched tumor subtypes.
Breast cancer genome-wide association studies (GWAS) in Hispanic/Latina (H/L) women in the United States and Latin American women have identified independent risk variants in the 6q25 region, including the protective variant rs140068132, located upstream of the Estrogen Receptor 1 (ESR1) gene. The molecular mechanisms...