Systemic sclerosis (SSc) is a complex autoimmune disease mainly characterized by progressive fibrosis affecting the skin and internal organs. Although several immunosuppressive and targeted therapies are currently available, many patients continue to experience refractory manifestations. Intravenous immunoglobulin...
J. D. de Carvalho, R. P. D. de Araújo, M. G. Danieli et al.· Frontiers in Immunology· 0 citations
Background: Treatment-resistant depression (TRD) represents a major clinical challenge, being associated with high morbidity, increased suicide risk, and substantial socioeconomic burden. The need for rapidly acting interventions has driven the development of rapid-acting antidepressants (RAADs), such as ketamine, eske...
J. D. de Carvalho, E. P. de Sena· Discover medicine· 0 citations
Background: Brittle nail syndrome is a common condition characterized by increased nail plate fragility, splitting, and breakage. Although oral supplements are widely marketed for nail health, evidence supporting individual substances, optimal doses, and combination regimens remains uncertain.
Objective: To critically...
J. D. de Carvalho, E. Hautz, Celso Roberto Cruz Da Colonia· International Journal of Pha...· 0 citations
Lipoprotein(a) [Lp(a)] is a lipoprotein particle predominantly determined by genetic factors and independently associated with atherosclerotic cardiovascular disease and calcific aortic valve stenosis. Although its recognition as a risk modifier has increased, few widely available interventions substantially lower its...
J. D. de Carvalho, R. P. D. de Araújo· International Journal of Med...· 0 citations
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