J. Davies

Distinct Lipid Binding Dynamics and Sodium Ion Coordination in the TRAP Transporter Hi SiaQM Revealed by Multiscale Molecular Dynamics Simulations

Tripartite ATP-independent periplasmic (TRAP) transporters are substrate-binding protein dependent secondary transporters that leverage ion gradients to facilitate substrate translocation across bacterial and archaeal membranes. Although the structure of HiSiaQM─a membrane-embedded TRAP subunit from the human pathoge...