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Open access Aug 2026

Sensitivity of pancreatic adenocarcinoma cells to blockade of post-initiation CDK-dependent Pol II transcription cycle checkpoints.

Pancreatic adenocarcinoma (PDAC) is a leading cause of cancer-related morbidity, with oncogenic KRAS/MAPK/ERK signalling arising from activating KRAS mutations being the key feature of this malignancy. Dysregulation of RNA polymerase II (Pol II)-dependent transcription is a universal hallmark of cancers including PDAC,...

Yvonne T Daniel, B. Martin, Nenad Bartonicek et al. · 0 citations
Review Open access Sep 2026

A guide to transcriptional cyclin-dependent kinases in cancer.

Transcriptional cyclin-dependent kinases (tCDKs) are master regulators of gene expression, controlling RNAPII activity and RNA synthesis across multiple phases of the transcription cycle. While highly controlled transcription is essential for all cellular processes and functions, aberrant gene expression or corrupted a...

J. Devlin, Salla Kyheröinen, Ricky W. Johnstone · 0 citations

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