Review
Open access
Aug 2026
Linking clinical trial data with real-world data for enhanced clinical evidence generation: methodological considerations and recommendations
Randomized controlled trials (RCTs) remain the cornerstone of causal inference on the safety and efficacy of medicinal products. But their limited follow-up, controlled settings, and narrowly defined data collection to balance the burden to patients and maintain study feasibility often results in unaddressed important...
A. Meinecke, J. Diaz-Decaro, Kathleen M. Gavin et al.
· Frontiers in Pharmacology · 1 citation