Author

J. E. Freedman

2 papers indexed here

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Open access Sep 2026

Paediatric proteomic signatures of cardiometabolic disease-associated traits predict adult disease outcomes

While the earliest pathological signs of cardiovascular–kidney–metabolic disease (CKMD) emerge before age 20, current adult-based risk thresholds fail to identify a substantial fraction of children at high risk. With increasing childhood obesity, early, sensitive detection of CKMD risk is critical to timely interventio...

Joshua M. Landman, Heather M. Highland, A. Perry et al. · Nature Metabolism · 0 citations

Open access Aug 2026

Dynamic cellular programs of human cardiac allograft rejection revealed by spatial transcriptomics

Allograft rejection following solid-organ transplantation is a major cause of graft dysfunction and mortality. Current diagnostic approaches rely on histology, which exhibits wide diagnostic variability and lacks clinically relevant molecular phenotyping. Here we leverage image-based spatial transcriptomics at subcellu...

Kaushik Amancherla, A. M. Taravella Oill, Xavier Bledsoe et al. · Nature Cardiovascular Resear... · 1 citation